We are cultivating a differentiated pipeline of small molecule medicines that utilize first-in-class or potential best-in-class mechanisms of action (MoAs) to reduce the neuronal hyperexcitability that underlies debilitating brain conditions including epilepsy. Our unique understanding of the complexities of neurologic systems allows us to turn preclinical potential into clinical meaning.

Our aim is to make a meaningful impact and address the significant unmet need in the lives of individuals with epilepsies and neurological disorders that present with brain conditions.

Program Indication Preclinical Phase 1 Phase 2 Phase 3 Approved
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OV888/GV101 capsule & ROCK2 Platform*

Selective ROCK2 inhibitor

Collaboration with Graviton logo
Brainstem cavernous malformations, undisclosed rare CNS indications

Completed

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OV329

GABA-aminotransferase inhibitor

In-licensed from Northwestern University logo
Oral formulation for chronic treatment of epilepsies
IV formulation for acute treatment of seizures
+
OV350 & KCC2 Platform

KCC2 transporter activators

In-licensed from Astra Zeneca
Resistant epilepsies and other neuropathologies
+
Soticlestat
Cholesterol 24-hydroxylase inhibitor Dravet syndrome

Completed

Out-licensed toTakeda logo Lennox-Gastaut syndrome

Completed

Drug Indication Stage
OV888/GV101 capsule & ROCK2 Platform*

Selective ROCK2 inhibitor

Collaboration with Graviton logo
Brainstem cavernous malformations, undisclosed rare CNS indications Phase 2
OV329

GABA-aminotransferase inhibitor

In-licensed from Northwestern University logo
Oral formulation for chronic treatment of epilepsies Phase 1
IV formulation for acute treatment of seizures Preclinical
OV350 & KCC2 Platform

KCC2 transporter activators

In-licensed from Astra Zeneca
Resistant epilepsies and other neuropathologies Preclinical
Soticlestat
Cholesterol 24-hydroxylase inhibitor Dravet syndrome Approved
Out-licensed toTakeda logo Lennox-Gastaut syndrome Approved

*Undisclosed ROCK2 inhibitor programs

Publications and Posters ยป